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Submit ReviewSelective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.
Geometric Isomer also available.
M. Wt | 329.17 |
Formula | C19H15FeNO |
Storage | Store at +4°C |
CAS Number | 1137967-28-2 |
PubChem ID | 90488891 |
InChI Key | MTGBTDOTYGXLBK-UHFFFAOYSA-M |
Smiles | [Fe++].[CH-]1C=CC=C1.O=C1NC2=CC=CC=C2\C1=C\C1=CC=C[CH-]1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors Metallomics 3 600 PMID: 21359402
Spencer et al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6 918
Keywords: (Z)-FeCP-oxindole, (Z)-FeCP-oxindole supplier, selective, human, VEGFR-2, inhibitors, inhibits, vascular, endothelial, cell, growth, factors, receptors, RTKs, receptor, tyrosine, kinases, VEGFR, 3883, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for (Z)-FeCP-oxindole.
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