(Z)-FeCP-oxindole

Discontinued Product

3883 has been discontinued.

View all VEGFR products.
Description: Selective VEGFR-2 inhibitor
Chemical Name: (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)

Biological Activity for (Z)-FeCP-oxindole

Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.

Geometric Isomer also available.

Technical Data for (Z)-FeCP-oxindole

M. Wt 329.17
Formula C19H15FeNO
Storage Store at +4°C
CAS Number 1137967-28-2
PubChem ID 90488891
InChI Key MTGBTDOTYGXLBK-UHFFFAOYSA-M
Smiles [Fe++].[CH-]1C=CC=C1.O=C1NC2=CC=CC=C2\C1=C\C1=CC=C[CH-]1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (Z)-FeCP-oxindole

References for (Z)-FeCP-oxindole

References are publications that support the biological activity of the product.

Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors Metallomics 3 600 PMID: 21359402

Spencer et al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6 918

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Keywords: (Z)-FeCP-oxindole, (Z)-FeCP-oxindole supplier, selective, human, VEGFR-2, inhibitors, inhibits, vascular, endothelial, cell, growth, factors, receptors, RTKs, receptor, tyrosine, kinases, VEGFR, 3883, Tocris Bioscience

Citations for (Z)-FeCP-oxindole

Citations are publications that use Tocris products.

Currently there are no citations for (Z)-FeCP-oxindole.

Reviews for (Z)-FeCP-oxindole

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for (Z)-FeCP-oxindole

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.