Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVU 590 dihydrochloride
Discontinued Product
3891 has been discontinued.
View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
Description: Inhibitor of Kir1.1 (ROMK) and Kir7.1
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
Purity: ≥97% (HPLC)
Biological Activity for VU 590 dihydrochloride
VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
Technical Data for VU 590 dihydrochloride
| M. Wt | 561.46 |
| Formula | C24H32N4O7.2HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1783987-83-6 |
| PubChem ID | 71433535 |
| InChI Key | FRYYSUBAHIUBNJ-UHFFFAOYSA-N |
| Smiles | O=[N+](C(C=C2)=CC=C2CN1CCOCCOCCN(CC3=CC=C([N+]([O-])=O)C=C3)CCOCC1)[O-].Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VU 590 dihydrochloride
References for VU 590 dihydrochloride
References are publications that support the biological activity of the product.
Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094 PMID: 19706730
View Related Products by Target
View Related Products by Product Action
Keywords: VU 590 dihydrochloride, VU 590 dihydrochloride supplier, Inhibitor, inhibitors, inhibits, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1, Inward, rectifier, Potassium, Channels, 3891, Tocris Bioscience
2 Citations for VU 590 dihydrochloride
Citations are publications that use Tocris products. Selected citations for VU 590 dihydrochloride include:
Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023
Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol 79 42 PMID: 20926757
Reviews for VU 590 dihydrochloride
Average Rating: 5 (Based on 1 Review.)
Have you used VU 590 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies.
By
Anonymous on 10/31/2018
Assay Type: In Vitro
Species: Human
Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies. The blocking effect showed by VU 590 is variable on the different classes of Kir channels. Overall acts as a great measure for comparing blocking action.
