Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPluripotin
Description: Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
Alternative Names: SC1
Chemical Name: N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for Pluripotin
Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).
Technical Data for Pluripotin
| M. Wt | 550.54 |
| Formula | C27H25F3N8O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 839707-37-8 |
| PubChem ID | 12003241 |
| InChI Key | NBZFRTJWEIHFPF-UHFFFAOYSA-N |
| Smiles | CN2C1=NC(NC4=CC(C)=NN4C)=NC=C1CN(C3=CC(NC(C5=CC(C(F)(F)F)=CC=C5)=O)=CC=C3C)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pluripotin
References for Pluripotin
References are publications that support the biological activity of the product.
Wu and Ding et al (2006) Applying chemical tools to the discovery of novel regenerative medicine. Drug Discov.Today Technol. 3 255
Chen et al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc.Natl.Acad.Sci.USA 103 17266 PMID: 17088537
Mertins et al (2013) A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One 8 e57099 PMID: 23437320
View Related Products by Target
View Related Products by Product Action
Keywords: Pluripotin, Pluripotin supplier, dual, inhibitors, inhibits, extracellular, signal-regulated, kinase, 1, ERK1, MAPK3, mitogen-activated, protein, 3, RasGAP, mouse, murine, stem, cells, self-renewal, SC1, ERK, Stem, Cell, Proliferation, 4433, Tocris Bioscience
Citations for Pluripotin
Citations are publications that use Tocris products.
Currently there are no citations for Pluripotin.
Reviews for Pluripotin
There are currently no reviews for this product. Be the first to review Pluripotin and earn rewards!
Have you used Pluripotin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Protocols for Pluripotin
The following protocol features additional information for the use of Pluripotin (Cat. No. 4433).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for Pluripotin
