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Submit ReviewTrifluorothymidine
Description: Thymidylate synthetase inhibitor
Chemical Name: α,α,α-Trifluorothymidine
Purity: ≥98% (HPLC)
Biological Activity for Trifluorothymidine
Trifluorothymidine is a nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.
Compound Libraries for Trifluorothymidine
Trifluorothymidine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Trifluorothymidine
| M. Wt | 296.2 |
| Formula | C10H11F3N2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 70-00-8 |
| PubChem ID | 6708818 |
| InChI Key | VSQQQLOSPVPRAZ-GFCOJPQKSA-N |
| Smiles | O=C1C(C(F)(F)F)=CN(C2O[C@H](CO)[C@@H](O)C2)C(N1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Trifluorothymidine
References for Trifluorothymidine
References are publications that support the biological activity of the product.
Okayama et al (2012) Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J.Pharmacol.Exp.Ther. 340 457 PMID: 22076553
Emura et al (2005) Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo. Int.J.Oncol. 27 449 PMID: 16010427
Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142 PMID: 25658371
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Keywords: Trifluorothymidine, Trifluorothymidine supplier, antitumor, anticancer, nucleoside, analog, thymidylate, synthase, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, Thymidylate, Synthetase, 4460, Tocris Bioscience
Citations for Trifluorothymidine
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Currently there are no citations for Trifluorothymidine.
Reviews for Trifluorothymidine
Average Rating: 5 (Based on 1 Review.)
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Anti-tumor activity of Trifluorothymidine was measured.
By
Anonymous on 12/23/2019
Species: Human
Cell Line/Tissue: HeLa human cervical cancer cell line
The HeLa human cervical cancer cell line was cultured in EMEM medium with 10% FCS. Anti-tumor activity of Trifluorothymidine was measured.
The rate of tumor growth (IR) inhibition was regarded as a measure of the antitumor efficacy and was calculated using the relative tumor volume (RTV) in the drug-treated groups (T) compared to that in the control group (C) using the following equation: IR (%) = (1 – T/C) × 100.
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Pathways for Trifluorothymidine
Apoptosis Signaling Pathway
Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.