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Submit ReviewUNC 926 hydrochloride
Description: L3MBTL1 domain inhibitor
Chemical Name: (3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for UNC 926 hydrochloride
UNC 926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay.
Technical Data for UNC 926 hydrochloride
| M. Wt | 373.72 |
| Formula | C16H21BrN2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1782573-49-2 |
| PubChem ID | 90488947 |
| InChI Key | DPPMBBHOXQOMJI-UHFFFAOYSA-N |
| Smiles | BrC1=CC=CC(C(N2CCC(N3CCCC3)CC2)=O)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UNC 926 hydrochloride
References for UNC 926 hydrochloride
References are publications that support the biological activity of the product.
Herold et al (2012) Structure-activity relationships of methyl-lysine reader antagonists. Med.Chem.Comm 3 45
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Keywords: UNC 926 hydrochloride, UNC 926 hydrochloride supplier, UNC926, Methyl-lysine, Kme, readers, antagonists, MBT, domains, L3MBTL1, histones, epigenetics, Other, Transcription, Factors, Domains, 4516, Tocris Bioscience
Citations for UNC 926 hydrochloride
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Currently there are no citations for UNC 926 hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.