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Submit ReviewTC AC 28
Description: High affinity BET bromodomain ligand
Chemical Name: 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester
Purity: ≥98% (HPLC)
Biological Activity for TC AC 28
TC AC 28 is a high affinity BET bromodomain ligand (Kd values are 40 and 800 nM for Brd2(2) and Brd2(1), respectively). Exhibits 20-fold selectively for the second over the first bromodomain.
Licensing Information
Sold under licence from the University of Dundee.
Technical Data for TC AC 28
| M. Wt | 415.44 |
| Formula | C23H21N5O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1809296-92-1 |
| PubChem ID | 118121364 |
| InChI Key | RARZHTSXOQRRPR-UHFFFAOYNA-N |
| Smiles | COC(CC1N=C(C2=CC(OC)=CC=C2N3C(C)=NN=C13)C4=C5C=CNC5=CC=C4)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC AC 28
References for TC AC 28
References are publications that support the biological activity of the product.
Baud et al (2016) New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition. J.Med.Chem. 59 1492 PMID: 26367539
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Keywords: TC AC 28, TC AC 28 supplier, TCAC28, BET, bromodomain, high, affinity, binding, agents, Bromodomains, 6105, Tocris Bioscience
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