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Zolmitriptan

Cat. No. 4657 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent 5-HT1B/1D/1F agonist
Chemical Name: (4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Zolmitriptan

Zolmitriptan is a potent 5-HT1B/1D/1F agonist (Ki values are 0.63, 5.01 and 63.09 nM for h5-HT1D, h5-HT1B and h5-HT1F receptors respectively). Inhibits trigeminal nerve stimulation-mediated neurogenic plasma protein extravasation in guinea pigs; blocks long excitatory postsynaptic potentials (EPSPs) in a rat model of spinal cord injury.

Compound Libraries for Zolmitriptan

Zolmitriptan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Zolmitriptan

M. Wt 287.36
Formula C16H21N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 139264-17-8
PubChem ID 60857
InChI Key ULSDMUVEXKOYBU-ZDUSSCGKSA-N
Smiles CN(C)CCC2=CNC1=CC=C(C[C@H](N3)COC3=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zolmitriptan

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.74 100
ethanol 28.74 100

Preparing Stock Solutions for Zolmitriptan

The following data is based on the product molecular weight 287.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.4 mL 34.8 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for Zolmitriptan

References are publications that support the biological activity of the product.

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J.Neurophysiol. 106 925 PMID: 21653728

Pauwels et al (1997) How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines. Neuropharmacology 36 499 PMID: 9225275

Martin et al (1997) Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). Br.J.Pharmacol. 121 157 PMID: 9154322

If you know of a relevant reference for Zolmitriptan, please let us know.

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Keywords: Zolmitriptan, Zolmitriptan supplier, 5ht, 5-ht, serotonergics, 5ht1B, 5ht1D, 5ht1F, potent, agonists, excitatory, postsynaptic, potentials, migraine, neurogenic, plasma, protein, extravasation, 5-HT1B, Receptors, 5-HT1D, 5-HT1F, 4657, Tocris Bioscience

1 Citation for Zolmitriptan

Citations are publications that use Tocris products. Selected citations for Zolmitriptan include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.