MEK

MEK, also known as Mitogen-activated protein kinase kinase and MAP2K, is a kinase enzyme that phosphorylates mitogen activated protein kinases (MAPKs), ERK, p38 and JNK. Seven MEK subtypes have so far been identified; MEK1 and MEK2 activate ERK, MEK3 and MEK4 activate p38 and MEK5 and MEK6 activate JNK. Upon activation, MAPKs can phosphorylate a variety of intracellular targets including transcription factors, transcriptional adaptor proteins, membrane and cytoplasmic substrates, and other protein kinases.

MEK is a key enzyme in the Ras/Raf/MEK/ERK signal transduction pathway and mediates cellular responses to different growth signals. This pathway is frequently deregulated in cancer, which makes these enzymes a candiate target for pharmacological antineoplastic treatment.

External sources of pharmacological information for MEK :

• BJP Guide

Literature for MEK

Tocris offers the following scientific literature for MEK to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

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Pathways for MEK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

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MEK Gene Data