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PD 334581

Cat. No. 4824 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: MEK1 inhibitor
Chemical Name: N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PD 334581

PD 334581 is an inhibitor of MEK1. Analog of PD 184352 (Cat. No. 4237).

Compound Libraries for PD 334581

PD 334581 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 334581

M. Wt 545.3
Formula C20H19F3IN5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 548756-68-9
PubChem ID 5287529
InChI Key LZZYEMSEMRUPIM-UHFFFAOYSA-N
Smiles FC1=CC(I)=CC=C1NC2=C(F)C(F)=CC=C2C3=NN=C(NCCN4CCOCC4)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PD 334581

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.53 100
ethanol 5.45 10

Preparing Stock Solutions for PD 334581

The following data is based on the product molecular weight 545.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.17 mL 18.34 mL
5 mM 0.37 mL 1.83 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for PD 334581

References are publications that support the biological activity of the product.

Zhang et al (2009) Targeting cancer with small molecule kinase inhibitors. Nat.Rev.Cancer 9 28 PMID: 19104514

Ohren et al (2004) Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel competitive kinase inhibition. Nat.Struct.Mol.Biol. 11 1192 PMID: 15543157

If you know of a relevant reference for PD 334581, please let us know.

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Keywords: PD 334581, PD 334581 supplier, PD334581, MEK1, kinase, inhibitors, inhibits, mitogen, activated, protein, 1, MEK, 4824, Tocris Bioscience

Citations for PD 334581

Citations are publications that use Tocris products.

Currently there are no citations for PD 334581. Do you know of a great paper that uses PD 334581 from Tocris? Please let us know.

Reviews for PD 334581

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for PD 334581

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.