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Submit ReviewTC NTR1 17
Description: Selective NTS1 partial agonist
Alternative Names: ML 301 analog
Chemical Name: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
Purity: ≥99% (HPLC)
Biological Activity for TC NTR1 17
TC NTR1 17 is a non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.
Compound Libraries for TC NTR1 17
TC NTR1 17 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for TC NTR1 17
| M. Wt | 522.98 |
| Formula | C27H27ClN4O5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1146757-96-1 |
| PubChem ID | 44157038 |
| InChI Key | ZQUSYVORYNBGLG-FQEVSTJZSA-N |
| Smiles | O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC NTR1 17
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.3 | 100 | |
| 1eq. NaOH | 26.15 | 50 |
Preparing Stock Solutions for TC NTR1 17
The following data is based on the product molecular weight 522.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.56 mL | 19.12 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets for TC NTR1 17
References for TC NTR1 17
References are publications that support the biological activity of the product.
Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID: 24332089
If you know of a relevant reference for TC NTR1 17, please let us know.
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Keywords: TC NTR1 17, TC NTR1 17 supplier, TCNTR117, ML301, analogs, non-peptide, selective, neurotensin, receptors, NTS1, NTR1, partial, agonists, ML, 301, analog, Neurotensin, Receptors, 5087, Tocris Bioscience
Citations for TC NTR1 17
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.