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NTRC 824

Cat. No. 5438 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective non-peptide NTS2 antagonist
Chemical Name: N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NTRC 824

NTRC 824 is a potent and selective non-peptide neurotensin (NTS) type-2 receptor antagonist (IC50 = 38 nM). Exhibits >150-fold selectivity for NTS2 over NTS1.

Compound Libraries for NTRC 824

NTRC 824 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NTRC 824

M. Wt 553.55
Formula C25H26F3N3O6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1623002-61-8
PubChem ID 101873359
InChI Key SOOLLEBJNGCDOZ-FQEVSTJZSA-N
Smiles O=C(C(F)(F)F)C2=CN(CC(N[C@@H](CC(C)C)C(O)=O)=O)C1=CC=C(NS(C3=CC=C(C)C=C3)(=O)=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NTRC 824

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.35 100
ethanol 55.35 100

Preparing Stock Solutions for NTRC 824

The following data is based on the product molecular weight 553.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References for NTRC 824

References are publications that support the biological activity of the product.

Thomas et al (2014) Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-L-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J.Med.Chem. 57 7472 PMID: 25157640

If you know of a relevant reference for NTRC 824, please let us know.

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Citations for NTRC 824

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.