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Submit ReviewCP 96345
Description: Potent and selective NK1 antagonist
Chemical Name: (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
Purity: ≥98% (HPLC)
Biological Activity for CP 96345
CP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for CP 96345
CP 96345 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CP 96345
| M. Wt | 412.57 |
| Formula | C28H32N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 132746-60-2 |
| PubChem ID | 104943 |
| InChI Key | FLNYLINBEZROPL-NSOVKSMOSA-N |
| Smiles | COC(C=CC=C3)=C3CN[C@H]1C(CC4)CCN4[C@H]1[C@H](C5=CC=CC=C5)C2=CC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CP 96345
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.25 | 20 with gentle warming |
Preparing Stock Solutions for CP 96345
The following data is based on the product molecular weight 412.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.12 mL | 60.6 mL | 121.19 mL |
| 1 mM | 2.42 mL | 12.12 mL | 24.24 mL |
| 2 mM | 1.21 mL | 6.06 mL | 12.12 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
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Product Datasheets for CP 96345
References for CP 96345
References are publications that support the biological activity of the product.
Snider et al (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251 435 PMID: 1703323
Lembeck et al (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 105 527 PMID: 1378337
Bang et al (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 305 31 PMID: 12649350
If you know of a relevant reference for CP 96345, please let us know.
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Keywords: CP 96345, CP 96345 supplier, Potent, selective, nonpeptide, NK1, receptors, antagonists, tachykinin, neurokinin, CP96345, Pfizer, Receptor, 2893, Tocris Bioscience
1 Citation for CP 96345
Citations are publications that use Tocris products. Selected citations for CP 96345 include:
Silva et al (2015) Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172 924 PMID: 25298144
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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