Sphingosine Kinase
Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.
Sphingosine Kinase Inhibitors |
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| Cat. No. | Product Name / Activity |
| 2097 | SKI II |
| Selective non-lipid inhibitor of sphingosine kinase | |
| 6281 | SLM 6031434 hydrochloride |
| Selective sphingosine kinase 2 (Sphk2) inhibitor | |
Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.
Sphingosine kinase is activated in response to pro-growth signals via GPCRs (e.g. acetylcholine muscarinic receptors), small GTPases and tyrosine kinase receptors (e.g. VEGFR and PDGFR). Once activated, sphingosine kinase translocates to the plasma membrane, a process aided by TNFα and PMA.
Due to its role in sphingosine-1-phosphate synthesis, SphK is a target of interest in cancer research.