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Submit Review3-Bromopyruvate
Description: MCT1 inhibitor; also inhibits hexokinase II
Chemical Name: 3-Bromo-2-oxopropanoic acid
Biological Activity for 3-Bromopyruvate
3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC50 = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.
Technical Data for 3-Bromopyruvate
| M. Wt | 166.96 |
| Formula | C3H3BrO3 |
| Storage | Store at -20°C |
| CAS Number | 1113-59-3 |
| PubChem ID | 70684 |
| InChI Key | PRRZDZJYSJLDBS-UHFFFAOYSA-N |
| Smiles | O=C(O)C(=O)CBr |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 3-Bromopyruvate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.7 | 100 |
Preparing Stock Solutions for 3-Bromopyruvate
The following data is based on the product molecular weight 166.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.99 mL | 29.95 mL | 59.89 mL |
| 5 mM | 1.2 mL | 5.99 mL | 11.98 mL |
| 10 mM | 0.6 mL | 2.99 mL | 5.99 mL |
| 50 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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Product Datasheets for 3-Bromopyruvate
References for 3-Bromopyruvate
References are publications that support the biological activity of the product.
Vander Linden et al (2021) Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell Rep. 35 109202 PMID: 34077729
Li et al (2022) Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiol. Dis. 163 105605 PMID: 34973450
If you know of a relevant reference for 3-Bromopyruvate, please let us know.
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Keywords: 3-Bromopyruvate, 3-Bromopyruvate supplier, MCT1, monocarboxylate, transporters, 1, inhibitors, inhibits, anticancer, hexokinase, antitumor, antitumour, apoptosis, Parkinsons, disease, Monocarboxylate, Transporters, Hexokinases, 7512, Tocris Bioscience
Citations for 3-Bromopyruvate
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