Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewA 971432
Description: Potent and selective S1P5 agonist
Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥99% (HPLC)
Biological Activity for A 971432
A 971432 is a potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.
Technical Data for A 971432
| M. Wt | 366.24 |
| Formula | C18H17Cl2NO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1240308-45-5 |
| PubChem ID | 46872626 |
| InChI Key | WAAWETUDFSIYSD-UHFFFAOYSA-N |
| Smiles | ClC1=C(Cl)C=C(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 971432
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 36.62 | 100 | |
| 1eq. HCl | 36.62 | 100 |
Preparing Stock Solutions for A 971432
The following data is based on the product molecular weight 366.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.73 mL | 13.65 mL | 27.3 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.73 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for A 971432
References for A 971432
References are publications that support the biological activity of the product.
Hobson et al (2015) Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P5) agonist for the potential treatment of neurodegenerative disorders. J.Med.Chem. 58 9154 PMID: 26509640
If you know of a relevant reference for A 971432, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: A 971432, A 971432 supplier, A971432, potent, selective, S1P5, sphingosine, phosphate, receptors, neurodegeneration, orally, bioavailable, blood-brain, barrier, Sphingosine-1-phosphate, Receptors, 5766, Tocris Bioscience
1 Citation for A 971432
Citations are publications that use Tocris products. Selected citations for A 971432 include:
Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684
Do you know of a great paper that uses A 971432 from Tocris? Please let us know.
Reviews for A 971432
There are currently no reviews for this product. Be the first to review A 971432 and earn rewards!
Have you used A 971432?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image