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α-Synuclein Degrader 2bn

Cat. No. 8041 Submit a Review Datasheet / COA / SDS
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Description: Negative control for α Synuclein Degrader 2b (Cat. No. 8040)
Chemical Name: 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for α-Synuclein Degrader 2bn

α-Synuclein Degrader 2bn is the negative control for α-Synuclein Degrader 2b (Cat. No. 8040).

Technical Data for α-Synuclein Degrader 2bn

M. Wt 781.82
Formula C40H43N7O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3034069-88-7
InChI Key FMDSDFONWFBVFG-UHFFFAOYSA-N
Smiles O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(N(C)C(CC7)=O)=O)=O)=C5C6=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for α-Synuclein Degrader 2bn

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.18 100

Preparing Stock Solutions for α-Synuclein Degrader 2bn

The following data is based on the product molecular weight 781.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.4 mL 12.79 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for α-Synuclein Degrader 2bn

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for α-Synuclein Degrader 2bn

References are publications that support the biological activity of the product.

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Citations for α-Synuclein Degrader 2bn

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia