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Description: Photoswitchable TRPV1 channel blocker
Chemical Name: 1,3,4,5-Tetrahydro-7,8-dihydro-N-[2-[4-[2-[4-(trifluoromethyl)phenyl]diazenyl]phenyl]ethyl]-2H-2-benzazepine-2-carbothioamide
Purity: ≥98% (HPLC)
Biological Activity for AC 4
AC 4 is a photoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.
Technical Data for AC 4
| M. Wt | 514.56 |
| Formula | C26H25F3N4O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1459809-09-6 |
| PubChem ID | 121513863 |
| InChI Key | COPZFJSJZPCWFD-UHFFFAOYSA-N |
| Smiles | S=C(NCCC3=CC=C(/N=N/C4=CC=C(C(F)(F)F)C=C4)C=C3)N(CCC2)CC1=C2C=C(O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AC 4
References for AC 4
References are publications that support the biological activity of the product.
Stein et al (2013) Optical control of TRPV1 channels. Angew.Chem.Int.Ed.Engl. 52 9845 PMID: 23873837
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Keywords: AC 4, AC 4 supplier, Photoswitchable, TRPV1, channel, blockers, transient, receptor, potential, vanilloids, ligands, Ligands, TRPV, 5464, Tocris Bioscience
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