Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAc-FLTD-CMK
Description: Potent and selective inhibitor of caspases 1, 5 and 4
Purity: ≥95% (HPLC)
Biological Activity for Ac-FLTD-CMK
Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.
Technical Data for Ac-FLTD-CMK
| M. Wt | 569.05 |
| Formula | C26H37ClN4O8 |
| Sequence |
FLTD (Modifications: Phe-1 = Ac-Phe, Asp-4 = Asp-CMK) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2376255-48-8 |
| PubChem ID | 155906572 |
| InChI Key | UCWNTWGHVCSMJP-WPUDHWPRSA-N |
| Smiles | O=C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)[C@H](CC1=CC=CC=C1)NC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ac-FLTD-CMK
| Solubility | Soluble to 1 mg/ml in DMSO |
Product Datasheets for Ac-FLTD-CMK
References for Ac-FLTD-CMK
References are publications that support the biological activity of the product.
Yang et al (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc.Natl.Acad.Sci.U.S.A. 115 6792 PMID: 29891674
If you know of a relevant reference for Ac-FLTD-CMK, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ac-FLTD-CMK, Ac-FLTD-CMK supplier, AcFLTDCMK, potent, selective, inhibitors, inhibits, caspases, inflammasome, pyroptosis, IL-b, IL-beta, caspase1, Caspases, 7242, Tocris Bioscience
Citations for Ac-FLTD-CMK
Citations are publications that use Tocris products.
Currently there are no citations for Ac-FLTD-CMK. Do you know of a great paper that uses Ac-FLTD-CMK from Tocris? Please let us know.
Reviews for Ac-FLTD-CMK
There are currently no reviews for this product. Be the first to review Ac-FLTD-CMK and earn rewards!
Have you used Ac-FLTD-CMK?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.