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Description: High affinity angiotensin-converting enzyme (ACE) ligand
Biological Activity for Acein
Acein is a high affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo.
Technical Data for Acein
| M. Wt | 932.5 |
| Formula | C43H68N10O13 |
| Sequence | PPTTTKFAA |
| Storage | Store at -20°C |
| PubChem ID | 122177132 |
| InChI Key | VFPBWEDFCUSZRJ-BRCVGTSGSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Acein
References for Acein
References are publications that support the biological activity of the product.
Neasta et al (2016) The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces DA release. Br.J.Pharmacol. 173 1314 PMID: 27027724
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Keywords: Acein, Acein supplier, High, affinity, angiotensin, converting, enzymes, ACE, ligands, Angiotensin-Converting, Enzyme, 6006, Tocris Bioscience
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