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Submit ReviewACPA (in Tocrisolve™ 100)
Description: Potent and selective CB1 agonist; supplied in water-soluble emulsion
Alternative Names: Arachidonylcyclopropylamide
Chemical Name: N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological Activity for ACPA (in Tocrisolve™ 100)
Potent and selective CB1 agonist (Ki = 2.2 nM), in water-soluble emulsion (for details see TocrisolveTM 100). Displays 325-fold selectivity over CB2 receptors and is active in vivo.
ACPA, pure oil dissolved in ethanol and Tocrisolve Control also available.
Technical Data for ACPA (in Tocrisolve™ 100)
| M. Wt | 343.55 |
| Formula | C23H37NO |
| Storage | Store at +4°C |
| CAS Number | 229021-64-1 |
| PubChem ID | 5311007 |
| InChI Key | GLGAUBPACOBAMV-DOFZRALJSA-N |
| Smiles | O=C(NC1CC1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ACPA (in Tocrisolve™ 100)
References for ACPA (in Tocrisolve™ 100)
References are publications that support the biological activity of the product.
Hillard et al (1999) Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J.Pharmacol.Exp.Ther. 289 1427 PMID: 10336536
Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884
Patel et al (2001) Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice. 2001 Symposium on the Cannabinoids, International
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Keywords: ACPA (in Tocrisolve 100), ACPA (in Tocrisolve 100) supplier, Potent, selective, CB1, agonists, water-soluble, emulsion, cannabinoids, Receptors, cb1r, Arachidonylcyclopropylamide, 1781, Tocris Bioscience
1 Citation for ACPA (in Tocrisolve™ 100)
Citations are publications that use Tocris products. Selected citations for ACPA (in Tocrisolve™ 100) include:
Niu et al (2012) Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats. Sleep 153 2283 PMID: 22940464
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
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