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Submit ReviewAH 7614
Description: Selective FFA4 (GPR120) antagonist
Chemical Name: 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for AH 7614
AH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for AH 7614
| M. Wt | 351.42 |
| Formula | C20H17NO3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 6326-06-3 |
| PubChem ID | 233085 |
| InChI Key | OZCQEUZTOAAWDK-UHFFFAOYSA-N |
| Smiles | CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AH 7614
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.14 | 100 |
Preparing Stock Solutions for AH 7614
The following data is based on the product molecular weight 351.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets for AH 7614
References for AH 7614
References are publications that support the biological activity of the product.
Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100 PMID: 24881566
If you know of a relevant reference for AH 7614, please let us know.
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Keywords: AH 7614, AH 7614 supplier, AH7614, selective, free, fatty, acid, 4, FFA4, receptor, antagonist, GPR120, Free, Fatty, Acid, Receptors, 5256, Tocris Bioscience
2 Citations for AH 7614
Citations are publications that use Tocris products. Selected citations for AH 7614 include:
Chen et al (2018) Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model. Mol Med 24 60 PMID: 30482157
Kishikawa et al (2019) Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation. Front Endocrinol (Lausanne) 10 157 PMID: 30949128
Do you know of a great paper that uses AH 7614 from Tocris? Please let us know.
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