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Submit Reviewα-Mangostin
Description: Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
Chemical Name: 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Purity: ≥98% (HPLC)
Biological Activity for α-Mangostin
α-Mangostin is a xanthone derivative. Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines. Also suppresses the invasive and metastatic ability of pancreatic CSCs by modulation of cadherin expression and suppressing the transcription factors Snail and Slug. Attenuates the expression of Nanog and pluripotency promoting transcription factors, and inhibits Nanog binding. Downregulates the PI 3-K/Akt pathway. Inhibits self-renewal of CSCs isolated from human primary tumors and KrasG12D mice. Inhibits MRSA and VRE. Antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic, anti-inflammatory, antioxidant and neuroprotective.
Technical Data for α-Mangostin
| M. Wt | 410.47 |
| Formula | C24H26O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 6147-11-1 |
| PubChem ID | 5281650 |
| InChI Key | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
| Smiles | COC1=C(CC=C(C)C)C2=C(OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O)C=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for α-Mangostin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.05 | 100 | |
| ethanol | 41.05 | 100 |
Preparing Stock Solutions for α-Mangostin
The following data is based on the product molecular weight 410.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.18 mL | 24.36 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets for α-Mangostin
References for α-Mangostin
References are publications that support the biological activity of the product.
Ma et al (2019) Inhibition of pancreatic cancer stem cell characteristics by a-Mangostin: Molecular mechanisms involving Sonic hedgehog and Nanog. J.Cell Mol.Med. 23 2719 PMID: 30712329
Wang et al (2017) Pharmacology of mangostins and their derivatives: A comprehensive review. Chin.J.Nat.Med. 15 81 PMID: 28284429
If you know of a relevant reference for α-Mangostin, please let us know.
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Citations for α-Mangostin
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Reviews for α-Mangostin
Average Rating: 5 (Based on 1 Review.)
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Anti-diabetic study employing alpha -Mangostin.
By
Joe Ques on 04/26/2024
Assay Type: In Vitro
Species: Human
Studied the anti-diabetic effects of alpha mangostin. The product performed well under study conditions and produced reproducible results.
alpha -mangostin at a concentration between 100-300 µg/ml used to understand insulin secretion change
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