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Submit ReviewAlytesin is an amphibian bombesin-like peptide. Stimulates gastric acid secretion, intestinal contraction, rat uterine contraction and hypertension in vivo in the dog. Also modulates thermoregulation following central administration in vivo.
M. Wt | 1535.78 |
Formula | C68H106N22O17S |
Sequence |
XGRLGTQWAVGHLM (Modifications: X = Glp, Met-14 = C-terminal amide) |
Storage | Desiccate at -20°C |
CAS Number | 31078-12-3 |
PubChem ID | 25078137 |
InChI Key | ISGGITPLKHZHOL-TXYKKBLVSA-N |
Smiles | [H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Anastasi (1971) Alytesin and bombesin, two peptide analogs from amphibian skin. Naunyn Schmiedebergs Arch.Pharmacol. 269 135 PMID: 4254272
Broccardo et al (1975) Relative potency of bombesin-like peptides. Br.J.Pharmacol. 55 221 PMID: 1201380
Rivier and Brown (1978) Bombesin, bombesin analogues, and related peptides: effects on thermoregulation. Biochemistry 17 1766 PMID: 656396
Keywords: Alytesin, Alytesin supplier, Amphibian, bombesin-like, peptide, GRP-Preferring, Receptors, BB1, BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, 1893, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.