Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAMP PNP
Description: Kir6 blocker; non-hydrolyzable AMP analog
Chemical Name: Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
Purity: ≥90% (HPLC)
Biological Activity for AMP PNP
AMP PNP is a non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.
Technical Data for AMP PNP
| M. Wt | 529.93 |
| Formula | C10H13Li4N6O12P3 |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 72957-42-7 |
| PubChem ID | 44134521 |
| InChI Key | FDBDJIGGLGUOPP-UHFFFAOYSA-J |
| Smiles | NC1=C2C(N([C@@H]3O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AMP PNP
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.5 | 50 |
Preparing Stock Solutions for AMP PNP
The following data is based on the product molecular weight 529.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.77 mL | 18.87 mL | 37.74 mL |
| 2.5 mM | 0.75 mL | 3.77 mL | 7.55 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for AMP PNP
References for AMP PNP
References are publications that support the biological activity of the product.
Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID: 2412134
Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID: 4326768
Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID: 7805625
If you know of a relevant reference for AMP PNP, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: AMP PNP, AMP PNP supplier, AMPPNP, non-hydrolyzable, non-hydrolysable, AMP, analog, adenylyl-imidodiphosphate, tetralithium, salt, Kir6, channel, blockers, blocks, KATP, inward, rectifier, potassium, current, Inward, Potassium, Channels, 6086, Tocris Bioscience
2 Citations for AMP PNP
Citations are publications that use Tocris products. Selected citations for AMP PNP include:
Shimizu et al (2021) Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin. Biochim.Biophys.Acta Biomembr. 1864 183782 PMID: 34555418
Roland et al (2021) Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv 7 eabk2392 PMID: 34936443
Do you know of a great paper that uses AMP PNP from Tocris? Please let us know.
Reviews for AMP PNP
Average Rating: 5 (Based on 1 Review.)
Have you used AMP PNP?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
AMP PNP was used to estimate Kir blocking on Natural Killer cells..
By
Anonymous on 01/16/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: NK cells
AMP PNP was used to estimate Kir blocking on Natural Killer cells at increasing concentrations.
