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Submit ReviewAPC 366
Description: Tryptase inhibitor
Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Purity: ≥95% (HPLC)
Biological Activity for APC 366
APC 366 is a selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.
Technical Data for APC 366
| M. Wt | 440.5 |
| Formula | C22H28N6O4 |
| Sequence | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 158921-85-8 |
| PubChem ID | 177340 |
| InChI Key | SKYWIMYOGAWOMB-IRXDYDNUSA-N |
| Smiles | OC2=C(C(N[C@@H](CCCNC(N)=N)C(N3[C@H]([C@](N)=O)CCC3)=O)=O)C=CC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for APC 366
| Solubility | Soluble to 5 mg/ml in 20% ethanol / water |
Product Datasheets for APC 366
References for APC 366
References are publications that support the biological activity of the product.
He et al (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 286 289 PMID: 9655871
Barrios et al (1998) Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 63 2295 PMID: 9877219
He et al (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 309 119 PMID: 14722328
Numerof et al (1997) Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs. 6 811
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Keywords: APC 366, APC 366 supplier, Tryptase, inhibitors, inhibits, mast, cell, Proteases, Proteinases, PAR, Receptors, Protease-Activated, proteinase-activated, APC366, Other, 2511, Tocris Bioscience
1 Citation for APC 366
Citations are publications that use Tocris products. Selected citations for APC 366 include:
Matsuda et al (2015) Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. Am J Transl Res 2015 635041 PMID: 26539519
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