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AS 1842856

Cat. No. 4265 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective Foxo1 inhibitor; orally bioavailable
Chemical Name: 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AS 1842856

AS 1842856 is a potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis both in vitro and in vivo. Attenuates fasting plasma glucose level in diabetic db/db mice. Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression. Also inhibits STAT3 signaling in NSCLC. Orally bioavailable.

Technical Data for AS 1842856

M. Wt 347.39
Formula C18H22FN3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 836620-48-5
PubChem ID 72193864
InChI Key MOMCHYGXXYBDCD-UHFFFAOYSA-N
Smiles CCN1C=C(C(C2=C(C(F)=C(C=C12)NC3CCCCC3)N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AS 1842856

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.74 5 with gentle warming

Preparing Stock Solutions for AS 1842856

The following data is based on the product molecular weight 347.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 57.57 mL 287.86 mL 575.72 mL
0.25 mM 11.51 mL 57.57 mL 115.14 mL
0.5 mM 5.76 mL 28.79 mL 57.57 mL
2.5 mM 1.15 mL 5.76 mL 11.51 mL

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Product Datasheets for AS 1842856

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for AS 1842856

References are publications that support the biological activity of the product.

Nagashima et al (2010) Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol.Pharmacol. 78 961 PMID: 20736318

Liu et al (2016) FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes. Cell Cycle 15 2033 PMID: 27260854

Galley et al (2019) Antagonism of forkhead box subclass O transcription factors elicits loss of soluble guanylyl cyclase expression. Mol.Pharmacol. 95 629 PMID: 30988014

If you know of a relevant reference for AS 1842856, please let us know.

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1 Citation for AS 1842856

Citations are publications that use Tocris products. Selected citations for AS 1842856 include:

Hye Jung et al (2022) P2Y2R-Mediated PAK1 Activation Is Involved in ESM-1 Overexpression in RT-R-MDA-MB-231 through FoxO1 Regulation. Cancers (Basel) 14 PMID: 36077661

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