Azurin p28 peptide

Name: Azurin p28 peptide
Brand: Tocris Bioscience
SKU: 7662

Cat. No. 7662 Submit a Review Datasheet / COA / SDS

Discontinued Product

7662 has been discontinued.

View all p53 products.

Description: Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53

Purity: ≥95% (HPLC)

Datasheet

Citations

Reviews

Literature (2)

Pathways (1)

Biological Activity Technical Data Datasheets References

Biological Activity for Azurin p28 peptide

Azurin p28 peptide is a 28 amino acid fragment of azurin (amino acids 50-77). The peptide is preferentially taken up by human breast cancer cell lines via caveolin-mediated endocytosis. Azurin p28 peptide binds wild-type and mutant p53 protein and inhibits E3 ligase COP1-mediated ubiquitination of p53 by >80%, resulting in decreased proteasomal degradation of p53. It induces cell cycle arrest in the G₂/M phase leading to apoptosis. Azurin p28 peptide exhibits antiproliferative effects in human breast cancer cells in vitro and in vivo.

Technical Data for Azurin p28 peptide

M. Wt	2914.2
Formula	C₁₂₂H₁₉₇N₃₁O₄₇S₂
Sequence	LSTAADMQGVVTDGMASGLDKDYLKPDD
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	897026-25-4
PubChem ID	53363312
InChI Key	RFGPECAMUVWTJN-AWHPYGDNSA-N
Smiles	O=C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Azurin p28 peptide

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Azurin p28 peptide

References are publications that support the biological activity of the product.

Yaghoubi et al (2020) p28 bacterial peptide, as an anticancer agent. Front.Oncol. 10 1303 PMID: 32850408

Yamada et al (2013) p28, a first in class peptide inhibitor of cop1 binding to p53. Br.J.Cancer 108 2495 PMID: 23736031

Yamada et al (2009) A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol.Cancer Ther. 8 2947 PMID: 19808975

View Related Products by Target

Keywords: Azurin p28 peptide, Azurin p28 peptide supplier, p53, binding, binds, COP1, E3, ligase, inhibitors, inhibits, breast, cancer, antiproliferative, tp53, Ubiquitin, Ligases, 7662, Tocris Bioscience

Citations for Azurin p28 peptide

Citations are publications that use Tocris products.

Currently there are no citations for Azurin p28 peptide.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

Cell Cycle and Mitosis
DNA Damage Repair
Targeted Protein Degradation
Ubiquitin Proteasome Pathway
Chemotherapy Targets

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for Azurin p28 peptide

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.