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Balicatib

Cat. No. 5585 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective cathepsin K inhibitor
Chemical Name: N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Balicatib

Balicatib is a potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.

Compound Libraries for Balicatib

Balicatib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Balicatib

M. Wt 411.54
Formula C23H33N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 354813-19-7
PubChem ID 10201696
InChI Key LLCRBOWRJOUJAE-UHFFFAOYSA-N
Smiles O=C(NC1(CCCCC1)C(NCC#N)=O)C(C=C2)=CC=C2N3CCN(CCC)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Balicatib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.15 100

Preparing Stock Solutions for Balicatib

The following data is based on the product molecular weight 411.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Balicatib

References are publications that support the biological activity of the product.

Desmarais et al (2008) Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 73 147 PMID: 17940194

If you know of a relevant reference for Balicatib, please let us know.

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Keywords: Balicatib, Balicatib supplier, cathepsins, K, inhibitors, potent, selective, inhibits, Cathepsin, 5585, Tocris Bioscience

1 Citation for Balicatib

Citations are publications that use Tocris products. Selected citations for Balicatib include:

Ting et al (2021) Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway. Cells 10 PMID: 34831087

Do you know of a great paper that uses Balicatib from Tocris? Please let us know.

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