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Submit ReviewBalicatib is a potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.
Balicatib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
M. Wt | 411.54 |
Formula | C23H33N5O2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 354813-19-7 |
PubChem ID | 10201696 |
InChI Key | LLCRBOWRJOUJAE-UHFFFAOYSA-N |
Smiles | O=C(NC1(CCCCC1)C(NCC#N)=O)C(C=C2)=CC=C2N3CCN(CCC)CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 41.15 | 100 |
The following data is based on the product molecular weight 411.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.43 mL | 12.15 mL | 24.3 mL |
5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
10 mM | 0.24 mL | 1.21 mL | 2.43 mL |
50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
References are publications that support the biological activity of the product.
Desmarais et al (2008) Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 73 147 PMID: 17940194
If you know of a relevant reference for Balicatib, please let us know.
Keywords: Balicatib, Balicatib supplier, cathepsins, K, inhibitors, potent, selective, inhibits, Cathepsin, 5585, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Balicatib include:
Ting et al (2021) Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway. Cells 10 PMID: 34831087
Do you know of a great paper that uses Balicatib from Tocris? Please let us know.
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