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Submit ReviewBAY 293
Description: Potent KRas/SOS1 interaction inhibitor
Chemical Name: (R)-6,7-Dimethoxy-2-methyl-N-[1-[4-[2-[(methylamino)methyl]phenyl]thiophene-2-yl]ethyl]quinazolin-4-amine
Purity: ≥98% (HPLC)
Biological Activity for BAY 293
BAY 293 is a potent KRas/son of sevenless 1 (SOS1) interaction inhibitor (IC50 = 21 nM); active R-enantiomer. Downregulates active RAS in tumor cells. Inhibits RAS-RAF-MEK-ERK pathway. Exhibits synergistic effects with KRASG12C inhibitor ARS-853.
Negative control also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 293 probe summary on the SGC website.
Compound Libraries for BAY 293
BAY 293 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BAY 293
| M. Wt | 448.59 |
| Formula | C25H28N4O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2244904-70-7 |
| InChI Key | WEGLOYDTDILXDA-OAHLLOKOSA-N |
| Smiles | CNCC1=C(C=CC=C1)C1=CSC(=C1)[C@@H](C)NC1=NC(C)=NC2=C1C=C(OC)C(OC)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BAY 293
References for BAY 293
References are publications that support the biological activity of the product.
Hillig et al (2019) Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc.Natl.Acad.Sci.USA. 116 2551 PMID: 30683722
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Keywords: BAY 293, BAY 293 supplier, BAY293, Potent, KRas/son, of, sevenless, 1, SOS1, interaction, inhibitors, inhibits, Ras, GTPases, 6857, Tocris Bioscience
Citations for BAY 293
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Currently there are no citations for BAY 293.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Pathways for BAY 293
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