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Submit ReviewBenazepril hydrochloride
Description: Angiotensin-converting enzyme (ACE) inhibitor
Alternative Names: CGS 14824A
Chemical Name: (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Benazepril hydrochloride
Benazepril hydrochloride is a non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.
Compound Libraries for Benazepril hydrochloride
Benazepril hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Benazepril hydrochloride
| M. Wt | 460.96 |
| Formula | C24H28N2O5.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 86541-74-4 |
| PubChem ID | 5362123 |
| InChI Key | VPSRQEHTHIMDQM-FKLPMGAJSA-N |
| Smiles | O=[C@@](OCC)[C@H](CCC3=CC=CC=C3)N[C@H]1CCC2=C(C=CC=C2)N(CC(O)=O)C1=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Benazepril hydrochloride
References for Benazepril hydrochloride
References are publications that support the biological activity of the product.
Takemori et al (1991) Effect of benaz. hydrochloride on cardiac hypertrophy in spontaneous hypertensive rats. Arzneim.-Forsch. 41 612
Ishibashi et al (1991) Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogs. Cardiovas.Drugs Ther. 5 635
Yamamoto et al (1991) General pharmacology of the novel angiotensin converting enzyme inhibitor benaz. hydrochloride. Effects on cardiovascular, visceral and renal functions and on hemodynamics. Arzneim.-Forsch. 41 913
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Keywords: Benazepril hydrochloride, Benazepril hydrochloride supplier, Angiotensin-converting, enzyme, ACE, inhibitors, inhibits, Proteinases, Proteases, CGS14824A, CGS, 14824A, Angiotensin-Converting, Enzyme, 2578, Tocris Bioscience
3 Citations for Benazepril hydrochloride
Citations are publications that use Tocris products. Selected citations for Benazepril hydrochloride include:
Li et al (2018) Characterization of UDP-Activated Purinergic Receptor P2Y6 Involved in Japanese Flounder Paralichthys olivaceus Innate Immunity. Int J Mol Sci 19 PMID: 30029501
Deng et al (2017) Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. J Pharmacol Exp Ther 360 215 PMID: 27821713
Bulavina et al (2013) NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal 9 199 PMID: 23208703
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