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Submit ReviewBenzbromarone
Discontinued Product
5420 has been discontinued.
View all Calcium-activated Chloride Channels products.
Description: TMEM16A/B calcium-activated chloride channel (CaCC) blocker
Chemical Name: (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)methanone
Purity: ≥99% (HPLC)
Biological Activity for Benzbromarone
TMEM16A/B calcium-activated chloride channel (CaCC) blocker. Inhibits ATP-induced mucin secretion and metacholine-induced airway smooth muscle contraction in vitro.
Technical Data for Benzbromarone
| M. Wt | 424.08 |
| Formula | C17H12Br2O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 3562-84-3 |
| PubChem ID | 2333 |
| InChI Key | WHQCHUCQKNIQEC-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC(Br)=C(O)C(Br)=C3)C2=C(CC)OC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Benzbromarone
References for Benzbromarone
References are publications that support the biological activity of the product.
Huang et al (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc.Natl.Acad.Sci.U.S.A. 109 16354 PMID: 22988107
Gallos et al (2013) Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am.J.Physiol.Lung Cell Mol.Physiol. 305 625 PMID: 23997176
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Keywords: Benzbromarone, Benzbromarone supplier, Benzbromarone, asthma, TMEM16A, TMEM16B, calcium, activated, chloride, channels, blockers, CACC, Ca2+-Activated, Chloride, Channels, 5420, Tocris Bioscience
Citations for Benzbromarone
Citations are publications that use Tocris products.
Currently there are no citations for Benzbromarone.
Reviews for Benzbromarone
Average Rating: 5 (Based on 1 Review.)
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Benzbromarone was used against Cav3.1 and Cav3.2 to understand its blocking capacities.
By
Anonymous on 02/27/2019
Species: Human
Benzbromarone was used against Cav3.1 and Cav3.2 to understand its blocking capacities in increasing concentrations.
Literature in this Area
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Benzbromarone
