BHPI

Cat. No. 6116 Submit a Review Datasheet / COA / SDS

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Description: ERα antagonist; also activates unfolded protein response; active in vivo

Chemical Name: 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BHPI

BHPI is an estrogen receptor (ER) α inhibitor. Inhibits proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. Induces sustained activation of the unfolded protein response. Active in vivo.

Compound Libraries for BHPI

BHPI is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BHPI

M. Wt	331.36
Formula	C₂₁H₁₇NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	56632-39-4
PubChem ID	3860640
InChI Key	FABLAHMQSQFDHR-UHFFFAOYSA-N
Smiles	CC1=CC=CC2=C1NC(C2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BHPI

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.14	100
	ethanol	33.14	100

Preparing Stock Solutions for BHPI

The following data is based on the product molecular weight 331.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.6 mL	3.02 mL	6.04 mL
10 mM	0.3 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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Product Datasheets for BHPI

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for BHPI

References are publications that support the biological activity of the product.

Andruska et al (2015) Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc.Natl.Acad.Sci.U.S.A. 112 4737 PMID: 25825714

If you know of a relevant reference for BHPI, please let us know.

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Keywords: BHPI, BHPI supplier, estrogen, receptor, alpha, ER, α, inhibitor, UPR, unfolded, protein, response, Estrogen, (GPER), Receptors, Other, stress/UPR, 6116, Tocris Bioscience

Citations for BHPI

Citations are publications that use Tocris products.

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Pathways for BHPI

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.