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Submit ReviewBI 9564
Description: Potent and selective BRD9 and BRD7 inhibitor; orally active
Chemical Name: 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
Purity: ≥98% (HPLC)
Biological Activity for BI 9564
BI 9564 is a potent and selective BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9564 probe summary on the SGC website.
External Portal Information for BI 9564
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI-9564 is reviewed on the chemical probes website.
Compound Libraries for BI 9564
BI 9564 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for BI 9564
| M. Wt | 353.41 |
| Formula | C20H23N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1883429-22-8 |
| PubChem ID | 117072549 |
| InChI Key | BJFSUDWKXGMUKA-UHFFFAOYSA-N |
| Smiles | O=C(N(C)C=C1C2=CC(OC)=C(CN(C)C)C=C2OC)C3=C1C=CN=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BI 9564
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.07 | 20 | |
| 1eq. HCl | 3.53 | 10 with gentle warming |
Preparing Stock Solutions for BI 9564
The following data is based on the product molecular weight 353.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.15 mL | 70.74 mL | 141.48 mL |
| 1 mM | 2.83 mL | 14.15 mL | 28.3 mL |
| 2 mM | 1.41 mL | 7.07 mL | 14.15 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.83 mL |
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Product Datasheets for BI 9564
References for BI 9564
References are publications that support the biological activity of the product.
Martin et al (2016) Structure-based design of an in vivo active selective BRD9 inhibitor J.Med.Chem. 59 4462 PMID: 26914985
Karim and Schönbrunn (2016) An Advanced Tool To Interrogate BRD9. J.Med.Chem. 59 4459 PMID: 27120693
If you know of a relevant reference for BI 9564, please let us know.
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Keywords: BI 9564, BI 9564 supplier, BI9564, BRD9, BRD7, potent, selective, inhibitors, inhibits, bromodomains, orally, active, Bromodomains, 5590, Tocris Bioscience
1 Citation for BI 9564
Citations are publications that use Tocris products. Selected citations for BI 9564 include:
Nasun et al (2022) BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A 119 PMID: 34983841
Do you know of a great paper that uses BI 9564 from Tocris? Please let us know.
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