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BMS 193885

Cat. No. 3242 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent, competitive NPY Y1 receptor antagonist
Chemical Name: 1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BMS 193885

BMS 193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.

Technical Data for BMS 193885

M. Wt 680.79
Formula C33H42N4O6.C3H6O3
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 679839-66-8
PubChem ID 56972234
InChI Key BYHJIPSVXAFCDI-WNQIDUERSA-N
Smiles CC1=C(C(OC)=O)C(C2=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=CC=C2)C(C(OC)=O)=C(C)N1.C[C@H](O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 193885

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.62 20
DMSO 68.08 100

Preparing Stock Solutions for BMS 193885

The following data is based on the product molecular weight 680.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.34 mL 14.69 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
10 mM 0.15 mL 0.73 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets for BMS 193885

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for BMS 193885

References are publications that support the biological activity of the product.

Poindexter et al (2004) Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements Bioorg.Med.Chem. 12 507 PMID: 14723969

Antal-Zimanyi et al (2008) Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist Eur.J.Pharmacol. 590 224 PMID: 18573246

Poindexter et al (2002) Dihydropyridine neuropeptide Y Y1 receptor antagonists. Bioorg.Med.Chem.Letts. 12 379

If you know of a relevant reference for BMS 193885, please let us know.

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Keywords: BMS 193885, BMS 193885 supplier, Potent, competitive, NPY, Y1, antagonists, Peptide, Receptors, Neuropeptide, Y, BMS193885, neuropeptides, 3242, Tocris Bioscience

1 Citation for BMS 193885

Citations are publications that use Tocris products. Selected citations for BMS 193885 include:

Acton et al (2019) Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep 28 625 PMID: 31315043

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.