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Submit ReviewBRL 52537 hydrochloride
Discontinued Product
0699 has been discontinued.
Description: Potent and selective κ agonist
Chemical Name: (±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for BRL 52537 hydrochloride
The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).
Licensing Information
Sold with the permission of GlaxoSmithKline
Technical Data for BRL 52537 hydrochloride
| M. Wt | 391.77 |
| Formula | C18H24Cl2N2O.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 112282-24-3 |
| PubChem ID | 11315337 |
| InChI Key | NGVLSOWJSUUYDE-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=CC=C(CC(=O)N2CCCCC2CN2CCCC2)C=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BRL 52537 hydrochloride
References for BRL 52537 hydrochloride
References are publications that support the biological activity of the product.
Vecchietti et al (1991) (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective κ opioid analgesics. J.Med.Chem. 34 397 PMID: 1846921
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Keywords: BRL 52537 hydrochloride, BRL 52537 hydrochloride supplier, Potent, selective, κ-opioid, kappa-opioid, agonist, agonists, KOP, Receptors, OP2, BRL52537, hydrochloride, GlaxoSmithKline, GSK, Kappa, Opioid, 0699, Tocris Bioscience
1 Citation for BRL 52537 hydrochloride
Citations are publications that use Tocris products. Selected citations for BRL 52537 hydrochloride include:
Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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