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Submit ReviewBRL 52537 hydrochloride
Description: Potent and selective κ agonist
Chemical Name: (±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for BRL 52537 hydrochloride
The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).
Licensing Information
Sold with the permission of GlaxoSmithKline
Technical Data for BRL 52537 hydrochloride
| M. Wt | 391.77 |
| Formula | C18H24Cl2N2O.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 112282-24-3 |
| PubChem ID | 11315337 |
| InChI Key | NGVLSOWJSUUYDE-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=CC=C(CC(=O)N2CCCCC2CN2CCCC2)C=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BRL 52537 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.96 | 5 with gentle warming |
Preparing Stock Solutions for BRL 52537 hydrochloride
The following data is based on the product molecular weight 391.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 51.05 mL | 255.25 mL | 510.5 mL |
| 0.25 mM | 10.21 mL | 51.05 mL | 102.1 mL |
| 0.5 mM | 5.11 mL | 25.53 mL | 51.05 mL |
| 2.5 mM | 1.02 mL | 5.11 mL | 10.21 mL |
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Product Datasheets for BRL 52537 hydrochloride
References for BRL 52537 hydrochloride
References are publications that support the biological activity of the product.
Vecchietti et al (1991) (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective κ opioid analgesics. J.Med.Chem. 34 397 PMID: 1846921
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1 Citation for BRL 52537 hydrochloride
Citations are publications that use Tocris products. Selected citations for BRL 52537 hydrochloride include:
Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702
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