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Description: Two-photon polarity-sensitive lipid membrane probe. Used for: cell membrane imaging. Application: One and Two-photon microscopy for membrane Polarity
Chemical Name: N-Methyl-N-[6-(1-oxododecyl)-2-naphthalenyl]glycine
Purity: ≥95% (HPLC)
Biological Activity for C-Laurdan
Key information: C-Laurdan is a polarity-sensitive lipid membrane probe.
Used for: lipid raft imaging and cell membrane imaging.
Application: One and two-photon microscopy for membrane polarity.
Properties and Photophysical Data: C-laurdan carry a carboxylic group which can be partially ionized which contributes to its good water solubility and fast membrane incorporation. Two photon excitation spectra = 780 nm. One photon excitation and emission maxima (λ) are 348 nm and 423 nm, respectively; quantum yield = 0.43; extinction coefficient = 12,200 M-1cm-1.
Optical Data for C-Laurdan
| Emission Color | Blue |
|---|---|
| λabs | 348 nm |
| λem | 423 nm |
| Extinction Coefficient (ε) | 12200 M-1cm-1 |
| Quantum Yield (φ) | 0.43 |
| Application | One and Two-photon Microscopy for Membrane Polarity |
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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data for C-Laurdan
| M. Wt | 397.56 |
| Formula | C25H35NO3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 959839-06-6 |
| PubChem ID | 24966947 |
| InChI Key | INSWREUMXDGFSD-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCC(C1=CC2=C(C=C(N(CC(O)=O)C)C=C2)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for C-Laurdan
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 39.76 | 100 | |
| ethanol | 3.98 | 10 | |
| DMSO | 7.95 | 20 |
Preparing Stock Solutions for C-Laurdan
The following data is based on the product molecular weight 397.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.15 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for C-Laurdan
References for C-Laurdan
References are publications that support the biological activity of the product.
Kim et al (2007) A two-photon fluorescent probe for lipid raft imaging: C-laurdan. Chembiochem 8 553 PMID: 17300111
Barucha-Kraszewska et al (2013) Will C-Laurdan dethrone Laurdan in fluorescent solvent relaxation techniques for lipid membrane studies? Langmuir 29 1174 PMID: 23311388
Mazeres et al (2014) Characterization of M-laurdan, a versatile probe to explore order in lipid membranes. F1000Res. 3 172 PMID: 25485094
If you know of a relevant reference for C-Laurdan, please let us know.
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Keywords: C-Laurdan, C-Laurdan supplier, fluorescent, probe, imaging, lipid, rafts, membrane, polarity, two-photon, 2-photon, one-photon, 1-photon, Fluorescent, Lipid, Probes, and, Cell, Membrane, Stains, 7273, Tocris Bioscience
1 Citation for C-Laurdan
Citations are publications that use Tocris products. Selected citations for C-Laurdan include:
Muriel et al (2021) Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast. EMBO J 40 e107966 PMID: 34520050
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Fluorescent Dyes and Probes Research Product Guide
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