Home / Pharmacology / Enzymes / ATPases / p97 ATPase / p97 ATPase Inhibitors / CB 5083

CB 5083

Cat. No. 7379 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent p97 ATPase inhibitor
Chemical Name: 1-[7,8-Dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CB 5083

CB 5083 is a potent p97 inhibitor, inhibiting the D2 ATPase domain (IC50 = 11 nM). CB 5083 shows broad antitumor activity and inhibits tumor growth in vivo. CB 5083 is cytotoxic to A549 cancer cells (IC50 = 680 nM) and reduces cell viablility in a range of colorectal cancer cell lines. Increases CHOP and GRP78 protein levels, upregulates PD-L1 mRNA levels and results in the loss of aggresomes.

Technical Data for CB 5083

M. Wt 413.48
Formula C24H23N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1542705-92-9
PubChem ID 73051434
InChI Key RDALZZCKQFLGJP-UHFFFAOYSA-N
Smiles O=C(N)C1=CC=CC2=C1C=C(N2C=3N=C(NCC=4C=CC=CC4)C5=C(N3)CCOC5)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CB 5083

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.35 100
ethanol 41.35 100

Preparing Stock Solutions for CB 5083

The following data is based on the product molecular weight 413.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.09 mL 24.18 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for CB 5083

References are publications that support the biological activity of the product.

Mukkavalli et al (2021) The p97-UBXN1 complex regulates aggresome formation. J.Cell Sci. 134 PMID: 33712450

Vekaria et al (2016) Targeting p97 to disrupt protein homeostasis in cancer. Front.Oncol. 6 PMID: 27536557

Vekaria et al (2019) Functional cooperativity of p97 and histone deacetylase 6 in mediating DNA repair in mantle cell lymphoma cells. Leukemia 33 1675 PMID: 30664664

Huryn et al (2019) p97: an emerging target for cancer, neurodegenerative diseases, and viral infections. J.Med.Chem. 63 1892 PMID: 31550150

Le Moigne et al (2017) The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma. Mol.Cancer Ther. 16 2375 PMID: 28878026

If you know of a relevant reference for CB 5083, please let us know.

View Related Products by Target

View Related Products by Product Action

View all p97 ATPase Inhibitors

Keywords: CB 5083, CB 5083 supplier, CB5083, p97, atpases, inhibitors, potent, tumor, antitumor, aggresome, valosin, containing, protein, VCP, colorectal, cancer, PD-L1, CRC, ATPase, 7379, Tocris Bioscience

Citations for CB 5083

Citations are publications that use Tocris products.

Currently there are no citations for CB 5083. Do you know of a great paper that uses CB 5083 from Tocris? Please let us know.

Reviews for CB 5083

There are currently no reviews for this product. Be the first to review CB 5083 and earn rewards!

Have you used CB 5083?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.