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Lac-Phe

Cat. No. 7942 Submit a Review Datasheet / COA / SDS
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Description: Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise
Chemical Name: N-[(2S)-2-Hydroxy-1-oxopropyl]-L-phenylalanine
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Lac-Phe

Lac-Phe is a metabolite generated from lactate and phenylalanine by cytosolic non-specific dipeptidase (CNDP2) during intense exercise. Lac-Phe reduces food intake in diet-induced obese mice without affecting movement or energy expenditure. When administrated chronically, Lac-Phe decreases adiposity and body weight and improves glucose homeostasis.

Technical Data for Lac-Phe

M. Wt 237.26
Formula C12H15NO4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 183241-73-8
PubChem ID 11075454
InChI Key IIRJJZHHNGABMQ-WPRPVWTQSA-N
Smiles C[C@H](O)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lac-Phe

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 100

Preparing Stock Solutions for Lac-Phe

The following data is based on the product molecular weight 237.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.07 mL 42.15 mL
5 mM 0.84 mL 4.21 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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References for Lac-Phe

References are publications that support the biological activity of the product.

Li et al (2022) An exercise-inducible metabolite that suppresses feeding and obesity. Nature 606 785 PMID: 35705806

If you know of a relevant reference for Lac-Phe, please let us know.

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Keywords: Lac-Phe, Lac-Phe supplier, Obesity, adipose, tissue, L-lactate-derived, DIO, lactoyl, phenylalanine, exercises, appetite, amino, acids, reverse, proteolysis, DNA,, RNA, and, Protein, Synthesis, 7942, Tocris Bioscience

Citations for Lac-Phe

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