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Cerulenin

Cat. No. 6702 Submit a Review Datasheet / COA / SDS

Discontinued Product

6702 has been discontinued.

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Description: Irreversible fatty acid synthase inhibitor
Chemical Name: (2R,3S)-3-[(4E,7E)-1-Oxo-4,7-nonadien-1-yl]-2-oxiranecarboxamide
Datasheet
Citations
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Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Cerulenin

Cerulenin is an irreversible fatty acid synthase inhibitor. Blocks proliferation of KRAS-driven lung cancer cells. Promotes apoptosis and inhibits necroptosis in cancer cells. Also inhibits protein palmitoylation and insulin uptake in rat adipocytes in vitro. Antibiotic.

Technical Data for Cerulenin

M. Wt 223.27
Formula C12H17NO3
Storage Store at -20°C
CAS Number 17397-89-6
PubChem ID 5282054
InChI Key GVEZIHKRYBHEFX-NQQPLRFYSA-N
Smiles C/C=C/C/C=C/CCC([C@H]1O[C@H]1C(N)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Cerulenin

References are publications that support the biological activity of the product.

Gouw et al (2017) Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma. Proc.Natl.Acad.Sci.U.S.A. 114 4300 PMID: 28400509

Parisi et al (2017) Very long chain fatty acids are functionally involved in necroptosis. Cell Chem.Bio. 24 1445 PMID: 29033315

Jochen et al (1995) Inhibitory effects of cerulenin on protein palmitoylation and Ins internalization in rat adipocytes. Biochim.Biophys.Acta. 1259 65 PMID: 7492617

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Citations for Cerulenin

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Currently there are no citations for Cerulenin.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including: