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Submit ReviewCGP 36216 hydrochloride
Description: GABAB antagonist; displays activity at presynaptic receptors
Chemical Name: (3-Aminopropyl)ethylphosphinic acid hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for CGP 36216 hydrochloride
CGP 36216 hydrochloride is a selective GABAB antagonist. Displays activity at presynaptic receptors; ineffective at GABAB postsynaptic receptors.
Compound Libraries for CGP 36216 hydrochloride
CGP 36216 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CGP 36216 hydrochloride
| M. Wt | 187.6 |
| Formula | C5H14NO2P.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1781834-71-6 |
| PubChem ID | 90488815 |
| InChI Key | CFQFXUJBWMPODB-UHFFFAOYSA-N |
| Smiles | O=P(CC)(CCCN)O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CGP 36216 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.76 | 100 | |
| DMSO | 18.76 | 100 |
Preparing Stock Solutions for CGP 36216 hydrochloride
The following data is based on the product molecular weight 187.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.33 mL | 26.65 mL | 53.3 mL |
| 5 mM | 1.07 mL | 5.33 mL | 10.66 mL |
| 10 mM | 0.53 mL | 2.67 mL | 5.33 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.07 mL |
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Product Datasheets for CGP 36216 hydrochloride
References for CGP 36216 hydrochloride
References are publications that support the biological activity of the product.
Ong et al (2001) CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain. Eur.J.Pharmacol. 415 191 PMID: 11274998
Froestl et al (1995) Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J.Med.Chem. 38 3313 PMID: 7650685
If you know of a relevant reference for CGP 36216 hydrochloride, please let us know.
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Keywords: CGP 36216 hydrochloride, CGP 36216 hydrochloride supplier, CGP36216, hydrochloride, gabab, antagonists, presynaptic, selective, GABAB, Receptors, 3219, Tocris Bioscience
1 Citation for CGP 36216 hydrochloride
Citations are publications that use Tocris products. Selected citations for CGP 36216 hydrochloride include:
Chen et al (2015) Morphine disinhibits glutamatergic input to VTA DA neurons and promotes DA neuron excitation. J Neurosci 4 PMID: 26208338
Do you know of a great paper that uses CGP 36216 hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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