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Submit ReviewCoraFluor™ 2, Haloalkane New
Description: Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand
Biological Activity for CoraFluor™ 2, Haloalkane
CoraFluor™ 2, Haloalkane is a cell permeable terbium-based time-resolved Förster resonance energy transfer (TR-FRET) donor for live cell TR-FRET assay development, such as target engagement and ternary complex assays. CoraFluor™ 2, Haloalkane is designed with a chloroalkane ligand for reactivity with haloalkane dehalogenase labeled proteins. CoraFluor™ 2, Haloalkane can be used in live cell intracellular TR-FRET assays. It is exceptionally bright, providing unmatched assay sensitivity and stability in biological media over other commercially available TR-FRET donors. CoraFluor™ 2, Haloalkane displays red shifted excitation and is excitable by both 365 nm and 405 nm lasers. It is compatible with common acceptor dyes such as FAM/FITC, AF488, GFP, mCherry, TMR and Cyanine 5, SE (Cat. No. 5436), enabling seamless assay integration in high throughput screening applications.
CoraFluor™ 1, Haloalkane, CoraFluor™ 1, thiol reactive, CoraFluor™ 1, amine reactive and CoraFluor™ 2, amine reactive also available.
CoraFluor is a trademark of Bio-Techne Corp.
Licensing Information
Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254
Optical Data for CoraFluor™ 2, Haloalkane
| λabs | 356 nm |
|---|---|
| Extinction Coefficient (ε) | 15900 M-1cm-1 |
| Quantum Yield (φ) | 0.35 |
| Closest Laser line | 337 nm |
| Cell Permeable | Yes |
| Application | Time-resolved fluorescence energy transfer (TR-FRET) |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectral Viewer
Technical Data for CoraFluor™ 2, Haloalkane
| M. Wt | 1662.7 |
| Storage | Store at -20°C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CoraFluor™ 2, Haloalkane
References for CoraFluor™ 2, Haloalkane
References are publications that support the biological activity of the product.
Payne et al (2021) Bright and stable luminescent probes for target engagement profiling in live cells. Nat.Chem.Biol. 17 1168 PMID: 34675420
If you know of a relevant reference for CoraFluor™ 2, Haloalkane, please let us know.
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Citations for CoraFluor™ 2, Haloalkane
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