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Submit ReviewCP 471474
Description: Broad spectrum MMP inhibitor
Chemical Name: 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
Purity: ≥97% (HPLC)
Biological Activity for CP 471474
CP 471474 is a broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for CP 471474
| M. Wt | 368.38 |
| Formula | C16H17FN2O5S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 210755-45-6 |
| PubChem ID | 9907286 |
| InChI Key | QCOQJYRPDUMCNP-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(OC2=CC=C(S(NC(C)(C)C(NO)=O)(=O)=O)C=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CP 471474
References for CP 471474
References are publications that support the biological activity of the product.
Rohde et al (1999) Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation 99 3063 PMID: 10368126
Lindsey et al (2002) Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation 105 753 PMID: 11839633
Fang et al (2007) Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J.Mol.Cell.Cardiol. 43 535 PMID: 17689559
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Keywords: CP 471474, CP 471474 supplier, CP471474, MMP, matrix, metalloproteinase, metalloprotease, inhibitors, inhibits, broad, spectrum, proteinases, proteases, Pfizer, Matrix, Metalloprotease, 3780, Tocris Bioscience
3 Citations for CP 471474
Citations are publications that use Tocris products. Selected citations for CP 471474 include:
Brafman et al (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. PLoS One 20 369 PMID: 23154389
Meierjohann et al (2010) MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9 201 PMID: 20667128
Zariffard et al (2015) Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. PLoS One 10 e0116911 PMID: 25611319
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