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CS 2100

Cat. No. 4543 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective S1P1 agonist
Chemical Name: 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CS 2100

CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.

Technical Data for CS 2100

M. Wt 461.53
Formula C25H23N3O4S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 913827-99-3
PubChem ID 11977938
InChI Key DWVJASHDNJMDNH-UHFFFAOYSA-N
Smiles CCC1=C(C2=NOC(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)SC(CN3CC(C(O)=O)C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CS 2100

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.31 5 with gentle warming

Preparing Stock Solutions for CS 2100

The following data is based on the product molecular weight 461.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 43.33 mL 216.67 mL 433.34 mL
0.25 mM 8.67 mL 43.33 mL 86.67 mL
0.5 mM 4.33 mL 21.67 mL 43.33 mL
2.5 mM 0.87 mL 4.33 mL 8.67 mL

Molarity Calculator

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Reconstitution Calculator

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References for CS 2100

References are publications that support the biological activity of the product.

Nakamura et al (2012) Synthesis and evaluation of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Eur.J.Med.Chem. 51 92 PMID: 22405291

Nakamura et al (2012) Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg.Med.Chem.Lett. 22 1788 PMID: 22264485

If you know of a relevant reference for CS 2100, please let us know.

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Citations for CS 2100

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