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Submit ReviewCycLuc 1
Description: Synthetic luciferase substrate; brain penetrant; displays NIR emission
Chemical Name: (4S)-2-(6,7-Dihydro-5H-pyrrolo[3,2-f]benzothiazol-2-yl)-4,5-dihydro-4-thiazolecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for CycLuc 1
CycLuc 1 is a synthetic luciferase substrate. Displays near-infrared (NIR) emission; peak luminescence at 599 nm. Suitable for use in in vivo bioluminescence imaging. Brain penetrant.
Optical Data for CycLuc 1
| Emission Color | Orange |
|---|---|
| λem | 600 nm |
| Cell Permeable | Yes |
| Application | In vivo bioluminescence Imaging (BLI) |
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Technical Data for CycLuc 1
| M. Wt | 305.37 |
| Formula | C13H11N3O2S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1247879-16-8 |
| PubChem ID | 91885395 |
| InChI Key | HBZBAMXERPYTFS-SECBINFHSA-N |
| Smiles | OC([C@H]1CSC(C2=NC3=C(C=C4NCCC4=C3)S2)=N1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CycLuc 1
References for CycLuc 1
References are publications that support the biological activity of the product.
Reddy et al (2010) Robust light emission from cyclic alkylaminoluciferin substrates for firefly luciferase. J.Am.Chem.Soc. 132 13586 PMID: 20828122
Evans et al (2014) A synthetic luciferin improves bioluminescence imaging in live mice. Nat.Methods. 11 393 PMID: 24509630
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Keywords: CycLuc 1, CycLuc 1 supplier, CycLuc1, luciferase, substrate, near, infrared, NIR, emission, bioluminescence, imaging, Bioluminescent, Substrates, 6823, Tocris Bioscience
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
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