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CYM 50260

Cat. No. 4677 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective S1P4 agonist
Chemical Name: 2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CYM 50260

CYM 50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.

Compound Libraries for CYM 50260

CYM 50260 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CYM 50260

M. Wt 350.6
Formula C14H11Cl3FNO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1355026-60-6
PubChem ID 44620894
InChI Key FHPOTBQOUBMMCI-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(OCCOC2=CC=C(CF)N=C2Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 50260

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.06 100

Preparing Stock Solutions for CYM 50260

The following data is based on the product molecular weight 350.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.26 mL 28.52 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References for CYM 50260

References are publications that support the biological activity of the product.

Guerrero et al (2011) Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg.Med.Chem.Lett. 22 537 PMID: 22119461

If you know of a relevant reference for CYM 50260, please let us know.

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1 Citation for CYM 50260

Citations are publications that use Tocris products. Selected citations for CYM 50260 include:

Matsushima-Nishiwaki R et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2 PLoS One 13 e0209050 PMID: 30543684

Do you know of a great paper that uses CYM 50260 from Tocris? Please let us know.

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