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Submit ReviewCYM 5442 hydrochloride
Description: Selective S1P1 receptor agonist
Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for CYM 5442 hydrochloride
CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
Compound Libraries for CYM 5442 hydrochloride
CYM 5442 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CYM 5442 hydrochloride
| M. Wt | 445.94 |
| Formula | C23H27N3O4.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1783987-80-3 |
| PubChem ID | 90488865 |
| InChI Key | KMZLVDAVGXYZDA-UHFFFAOYSA-N |
| Smiles | OCCNC3CCC(C3=CC=C4)=C4C1=NOC(C2=CC(OCC)=C(OCC)C=C2)=N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CYM 5442 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.59 | 100 |
Preparing Stock Solutions for CYM 5442 hydrochloride
The following data is based on the product molecular weight 445.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.21 mL | 22.42 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets for CYM 5442 hydrochloride
References for CYM 5442 hydrochloride
References are publications that support the biological activity of the product.
Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 74 1308 PMID: 18708635
If you know of a relevant reference for CYM 5442 hydrochloride, please let us know.
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Keywords: CYM 5442 hydrochloride, CYM 5442 hydrochloride supplier, sphingosine-1-phosphate, S1P1, receptors, agonists, CYM5442, hydrochloride, Sphingosine-1-phosphate, Receptors, 3601, Tocris Bioscience
6 Citations for CYM 5442 hydrochloride
Citations are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:
Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830
Li et al (2015) Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation 12 70 PMID: 25880547
Balaji M et al (2021) Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem 296 100386 PMID: 33556374
Masato et al (2018) Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Cell 174 636-648.e18 PMID: 30017246
Chumanevich et al (2016) Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. Mediators Inflamm 2016 1503206 PMID: 26884643
Janes et al (2014) The development and maintenance of PacT.-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem 289 21082 PMID: 24876379
Do you know of a great paper that uses CYM 5442 hydrochloride from Tocris? Please let us know.
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