Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCYM 5541
Description: Selective S1P3 receptor allosteric agonist
Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Purity: ≥97% (HPLC)
Biological Activity for CYM 5541
CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.
Compound Libraries for CYM 5541
CYM 5541 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CYM 5541
| M. Wt | 316.44 |
| Formula | C19H28N2O2 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 945128-26-7 |
| PubChem ID | 17253208 |
| InChI Key | NDKGACIWVAOUQH-UHFFFAOYSA-N |
| Smiles | O=C(N(C3CCCCC3)C2CCCCC2)C1=NOC(C4CC4)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CYM 5541
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.64 | 100 | |
| ethanol | 15.82 | 50 |
Preparing Stock Solutions for CYM 5541
The following data is based on the product molecular weight 316.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.8 mL | 31.6 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for CYM 5541
References for CYM 5541
References are publications that support the biological activity of the product.
Jo et al (2012) Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem.Biol. 7 1975 PMID: 22971058
If you know of a relevant reference for CYM 5541, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CYM 5541, CYM 5541 supplier, CYM5541, Selective, S1P3, receptors, allosteric, agonists, SIP, Sphingosine-1-phosphate, Sphingosine, Receptors, 4897, Tocris Bioscience
6 Citations for CYM 5541
Citations are publications that use Tocris products. Selected citations for CYM 5541 include:
O'Sullivan et al (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Nat Commun 13 31 PMID: 26856814
Antonio et al (2020) Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun 11 3987 PMID: 32778678
Tzu-Ming et al (2020) Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis. J Pharmacol Exp Ther 375 357-366 PMID: 32848074
Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927
Balaji M et al (2021) Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem 296 100386 PMID: 33556374
Do you know of a great paper that uses CYM 5541 from Tocris? Please let us know.
Reviews for CYM 5541
There are currently no reviews for this product. Be the first to review CYM 5541 and earn rewards!
Have you used CYM 5541?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image