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Submit ReviewDEL 22379
Description: ERK dimerization inhibitor
Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
Purity: ≥98% (HPLC)
Biological Activity for DEL 22379
DEL 22379 is an ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.
Technical Data for DEL 22379
| M. Wt | 444.53 |
| Formula | C26H28N4O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 181223-80-3 |
| PubChem ID | 11224574 |
| InChI Key | INQUULPXCZAKMS-XKZIYDEJSA-N |
| Smiles | O=C1NC2=CC=C(NC(CCN3CCCCC3)=O)C=C2/C1=C/C4=CNC5=C4C=C(OC)C=C5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DEL 22379
References for DEL 22379
References are publications that support the biological activity of the product.
Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170 PMID: 26267534
Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183 PMID: 26858988
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Keywords: DEL 22379, DEL 22379 supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, 5774, Tocris Bioscience
1 Citation for DEL 22379
Citations are publications that use Tocris products. Selected citations for DEL 22379 include:
Saranya Santhosh et al (2019) The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. Cell 179 1306-1318.e18 PMID: 31761535
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for DEL 22379
