Digoxin

Cat. No. 4583 5 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Na⁺/K⁺ ATPase inhibitor

Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one

Purity: ≥98% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Digoxin

Digoxin is an inhibits membrane-bound α-subunits of the Na⁺/K⁺ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na⁺/K⁺ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 0.17 μM).

Technical Data for Digoxin

M. Wt	780.94
Formula	C₄₁H₆₄O₁₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	20830-75-5
PubChem ID	12940973
InChI Key	LTMHDMANZUZIPE-PUGKRICDSA-N
Smiles	O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@@]5(C[C@H](CC[C@@]5([C@]4(C[C@H]([C@@]32C)O)[H])C)O[C@@]6(O[C@@H]([C@H]([C@H](C6)O)O[C@]7(C[C@@H]([C@@H]([C@H](O7)C)O[C@@]8(O[C@@H]([C@H]([C@H](C8)O)O)C)[H])O)[H])C)[H])[H])=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Digoxin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	78.09	100

Preparing Stock Solutions for Digoxin

The following data is based on the product molecular weight 780.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.28 mL	6.4 mL	12.81 mL
5 mM	0.26 mL	1.28 mL	2.56 mL
10 mM	0.13 mL	0.64 mL	1.28 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

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Product Datasheets for Digoxin

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Digoxin

References are publications that support the biological activity of the product.

Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325 PMID: 15970498

Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959 PMID: 15210613

Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500 PMID: 22695717

Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958

If you know of a relevant reference for Digoxin, please let us know.

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Keywords: Digoxin, Digoxin supplier, cardiac, glycoside, digitalis, sodium, potassium, ATP, Na+, K+, ATPase, pump, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Na+/K+, Coronavirus, 4583, Tocris Bioscience