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Submit ReviewDIM
Description: Inhibits EGFR activation; also induces apoptosis
Alternative Names: 3,3-Diindolylmethane
Chemical Name: 3,3'-Methylenediindole
Purity: ≥99% (HPLC)
Biological Activity for DIM
DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
Technical Data for DIM
| M. Wt | 246.31 |
| Formula | C17H14N2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1968-05-4 |
| PubChem ID | 10900930 |
| InChI Key | SHXKYUYEFDONQC-UHFFFAOYSA-N |
| Smiles | C12=CC=CC=C1C(CC3=CC(C=CC=C4)=C4N3)=CN2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DIM
References for DIM
References are publications that support the biological activity of the product.
Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24 PMID: 22205686
Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297 PMID: 20444961
Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975 PMID: 22514694
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Keywords: DIM, DIM supplier, Chk2, checkpoint, kinase, 2, activators, antiproliferatives, anticancer, chemotherapeutics, epidermal, growth, factor, receptors, EGFR, inhibitors, inhibits, pro-apoptotic, apoptosis, inducers, 3,3-diindolylmethane, 3,3-Diindolylmethane, Checkpoint, Control, Kinases, Cell, Cycle, Inhibitors, Other, Apoptosis, 4502, Tocris Bioscience
Citations for DIM
Citations are publications that use Tocris products.
Currently there are no citations for DIM.
Reviews for DIM
Average Rating: 5 (Based on 1 Review.)
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Determination of DIM suppression of EGFR.
By
Anonymous on 12/14/2019
Species: Human
To determine whether DIM suppressed the activation of EGFR by activating phosphorylation, cells were treated with epidermal growth factor.
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